TITLE: Professor

NAME: Joseph Bamidele Minari

POSITION: Professor

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)

Personal Statement:

J.B.Minari is a Professor of Cell Physiology and Molecular Biology in the department of Cell Biology and Genetics, Faculty of Science, University of Lagos with specialization in molecular biology and genome editing of cancer and viral infectious diseases. As PI and Co-investigator of both University and other grant-warding organizations, I have screened, characterized, studied and research into discovery of potential antitumor and antiviral compound and their possible target. This will definitely help to discover and validate natural product which is readily available, cheap and effective for breast cancer therapy and infectious diseases.  I have taught and supervised research work on enzymology, molecular biology and genome editing at both undergraduate and postgraduate level. I am currently using CRISPR technology in enhancing treatment of cancer of exiting drugs and natural product. The team of Cancer and Genome Editing Research Group in the department of Cell Biology and Genetics which I lead also organizes hands-on training on CRISPR technology in resolving real life problems in Africa.

Ongoing and completed research work that I will like to highlight:

1. University of Lagos CRC grant CRC NO. 2018/12  Minari (PI) Genetic expression of p21 and CDK1 protein in MCF7 cell line and MNU-induced breast cancer treated with Olax Subscorpioidea and Newboidia leaves.
2. UK GCFR_NF98 EWS COVID -19 GRANT Co-investigator, Building an Early Warning System for community-wide infectious disease spread: SARSCoV-2 tracking in Africa via environment fingerprinting.                                                 
3. Lasric grant 2020. Co-investigator, Immuno-informatics Design of an Epitope Peptide Based Vaccine against SARS-CoV-2 Spike Glycoprotein.                    
4. Tetfund Grant – TETF/DR&D/CE/NRF2020/SETI/39/VOL 1 Minari (PI) Candidate Blockers Identification For RNA Dependent RNA Polymerase As Potential Drugs For Covid-19.
5. Minari (PI) CRISPR-Cas 9 assisted Anti-cancer property of curcumin and Resveratrol as Potential Drug candidate for Breast Cancer

Positions, Scientific Appointment and Honors

1. 2018-2021- National Vice President, Nigerian Society for Experimental Biology

• 2009- Present-Member, West African Bioinformatics Research Initiative
• 2009- Present- Member Nigerian Society of Biochemistry and Molecular Biology
• 2013- Present- Member Biochemical Society UK
• 2013- Present- Member The American Society for Biochemistry and Molecular Biology
• 2014- Present- Secretary, Society for Forensic and Analytical Scientists, Nigeria
• 2018-2021 -Sub-Dean, Faculty of Science                                                                                                                                                     

Selected Most Recent Publications/Contributions to Knowledge

1. Minari, J.B. , Okeke U.(2014). Chemopreventive effect of Amona muricata on DMBA-induced cell proliferation in breast tissues of female albino mice. Egyptian Journal of Medical and Human Genetics. 15: 327-334 –  ELSEVIER.
2. J.B. Minari , G.O. Ogar , A.J. Bello (2016).Antiproliferative potential of aqueous leaf extract of Mucuna pruriens on DMBA-induced breast cancer in female albino rats. Egyptian Journal of Medical and Human Genetics.  17: 331-343. –  ELSEVIER.
3. Godwin Offumobi Ogar, Joseph Bamidele Minari, Adebayo Joseph Bello, Janet Chiwetalu, Oluwafunto Eunice Omogunwa, Oluwadamilola Suzan Oshikoya, Micheal Tobiloba Otaru, Chioma Anastacia Anyanele (2022). Influence of Ethanolic Extract of Allium sativum on TP53 gene and its anticancer potential in N-Nitrosodiethylamine (NDEA)-Induced Hepatocellular Carcinoma in Male Albino Rats. Iranian Journal of Basic Medical Sciences. 25: 497-505.
4. Joseph Bamidele MINARI,  Gift Ezinna NWOSU, Idowu Samuel DADA, Dhikrullah Oluwatope, ABDULAZEEZ, (2024). Isolation and Characterization of Amylase Produced By CRISPR-Cas 9 Edited Lac Z Gene and Unedited Escherichia Coli Using Potatoe Peel (Ipomea Batata) as Enzyme Sour. Journal of Applied Sciences and Environmental Management 28 (10), 2981-2989.
5. Joseph Bamidele MINARI,  Idowu Samuel DADA, /Dhikrullah Oluwatope, Abdulazeez, Gift E. NWOSU, (2024). CRISPR-CAS9 mediated editing of the lacz gene for optimizing lipase production and characterization in engineered escherichia coli using potato peel as a glucose source. bioRxiv, 2024.09. 02.608350.

Collaborators/Networks(International inclusive)

• 2023 to Date – Alumnus TReND Africa
• 2025 – Ambassador GeneforAll
• 2025 – NICRAT Collaborator