Biochemistry Prospectus

FOUR YEAR DEGREE PROGRAMME IN BIOCHEMISTRY

100 LEVEL FIRST SEMESTER

COURSE CODE

OLD COURSE CODE

COURSE TITLE

STATUS

UNITS

FSC 111

FSC 101

Introductory Biology

C

3

FSC 112

FSC 102

Introductory Chemistry

C

3

FSC 113

FSC 103

Introductory Computer Science

C

3

FSC 114

FSC 104

Introductory Mathematics

C

3

FSC 115

FSC 105

Introductory Physics

C

3

GST 102

GST 102

Philosophy and Logic

C

2

GST 105

GST 105

Use of English

C

2

ZLY 111

ZLY 101

Introductory Zoology I

C

2

TOTAL UNITS OF COMPULSORY COURSES:

TOTAL UNITS OF ELECTIVE COURSES AVAILABLE:

Total:

21

 0

21

100 LEVEL SECOND SEMESTER

COURSE CODE

OLD COURSE CODE

COURSE TITLE

STATUS

UNITS

CHM 121

CHM 101

Introductory Chemistry II

C

3

CHM 122

CHM 102

Experimental Chemistry I

C

2

BTN 121

BTN 101

General Botany

C

3

GST 103

GST 103

History of Nigerian Peoples and Cultures

C

2

PHS 123

PHS 101

Introductory Physics II

C

2

ZLY 121

ZLY 102

Introductory Zoology II

E

2

CSC 120

CSC 100

Computer as a Problem Solving Tool

E

3

MAT 122

MAT 101

Calculus

E

2

PHS 122

PHS 102

Introductory Physics III

E

3

PHS 121

PHS 103

Introductory Practical Physics

E

2

STA 121

MAT 104

Statistics for Scientists

E

3

MSF 120

MBF 101

Introduction to Fisheries

E

3

TOTAL UNITS OF COMPULSORY COURSES:

TOTAL UNITS OF ELECTIVE COURSES AVAILABLE:

                              Total:

12

18

30

200 LEVEL FIRST SEMESTER

COURSE CODE

OLD COURSE CODE

COURSE TITLE

STATUS

UNITS

BCH 211

BCH 201

Introductory Biochemistry I

C

2

BCH 212

BCH 201

General Biochemistry Practical I

C

1

BCH 213*

BCH 203

Acid Base Chemistry

E

3

CHM 213

CHM 203

Basic Organic Chemistry I

C

3

FRE 137

FRE 187

French for Science and Professional Studies I

C

3

GST 201

GST 201

General African Studies

C

2

MIC 211

MIC 201

Basic Microbiology I

C

3

CHM 211

CHM 201

Basic Inorganic Chemistry I

C

2

CHM 214

CHM 204

Experimental Chemistry II (Physical & Inorganic)

E

2

CBG 211

BIY 201

Cell Biology

E

3

BTN 211

BTN 201

Variety of Plants I

E

3

MAT 217

MAT 213

Pure Mathematics I

E

2

ZLY 211

ZLY 202

General Zoology

E

3

TOTAL UNITS OF COMPULSORY COURSES:

 TOTAL UNITS OF ELECTIVE COURSES AVAILABLE:

                       Total:

16

13

29

*Course for Physiotherapy Students. Not available for Biochemistry Students.

                                                                       200 LEVEL SECOND SEMESTER

COURSE CODE

OLD COURSE CODE

COURSE TITLE

STATUS

UNITS

BCH 222

BCH 202

Introductory Biochemistry II

C

3

CHM 222

CHM 202

Basic Physical Chemistry

C

2

CHM 224

CHM 205

Experimental Chemistry III (Organic)

C

2

FRE 147

FRE 188

French for Science and Professional Studies I

C

2

BTN 221

BTN 202

Variety of Plants II

E

3

CSC 227

CSC 207

Introduction to Information Processing

E

3

MIC 222

MIC 202

Basic Microbiology II

C

3

ZLY 221

ZLY 202

Animal Structure and Function II

E

3

ZLY 222

ZLY 203

Man and His Environment

E

2

TOTAL UNITS OF COMPULSORY COURSES:

TOTAL UNITS OF ELECTIVE COURSES AVAILABLE:

                                                                                                                                          Total:

12

11

23

300 LEVEL FIRST SEMESTER

COURSE CODE

OLD COURSE CODE

COURSE TITLE

STATUS

UNITS

FSC 311

FSC 301

History and Philosophy of Science

C

2

BCH 310

BCH 304

Bioenergetics

C

1

BCH 311

BCH 306

Introductory Enzymology

C

3

BCH 312

BCH 302/304

Chemistry and Metabolism of Carbohydrates

C

2

BCH 313

BCH 302/304

Chemistry and Metabolism of Lipids

C

2

BCH 314

BCH 307

Analytical Methods in Biochemistry

C

3

BCH 315

BCH 307

General Biochemistry Practical II

C

2

BCH 316*

BCH 300

General Biochemistry (Non-majors)

E

3

CBG 312

CBG 302

Genetics I

E

2

CHM 313

CHM 314

Experimental Chemistry V

E

2

CHM 314

CHM 305

Applied Spectroscopy

E

2

GST 307

GST 307

Entrepreneurship

C

2

STA 314

MAT 317

Statistics for Biologists

E

3

TOTAL UNITS OF COMPULSORY COURSES:

TOTAL UNITS OF ELECTIVE COURSES AVAILABLE:

                                                                                                                                                Total:

17

9

24

*Course for Non-Biochemistry Majors. Not available for Biochemistry Students.

300 LEVEL SECOND SEMESTER

COURSE CODE

OLD COURSE CODE

COURSE TITLE

STATUS

UNITS

BCH 320

BCH 406

Principles of Endocrinology

C

2

BCH 321

BCH 308

Principles of Immunology

C

2

BCH 322

BCH301/304

Chemistry and Metabolism of Amino acids and Proteins

C

2

BCH 323

BCH 301/304

Chemistry and Metabolism of Nucleic acids

C

2

BCH 324

BCH 407

Nutritional Biochemistry

C

2

BCH 325

 

Toxicology I

C

2

CHM 322

CHM 304

Organic Reactions

E

3

CHM 321

CHM 302

Transition Metal Chemistry

E

3

SIW 321

SIW 300

Industrial Attachment II (12 weeks)

C

3

 TOTAL UNITS OF COMPULSORY COURSES:

       TOTAL UNITS OF ELECTIVE COURSES AVAILABLE:

                         Total:

15

6

21

400 LEVEL FIRST SEMESTER

COURSE CODE

OLD COURSE CODE

COURSE TITLE

STATUS

UNITS

BCH 410

BCH 405

Advanced Biochemical Methods

C

2

BCH 411

BCH 402

Enzymology

C

2

BCH 412

BCH 401

Biosynthesis of Macromolecules

C

1

BCH 413

BCH 310

Pharmacological Biochemistry

E

2

BCH 414

BCH 401

Bioinorganic Chemistry

E

1

BCH 415

 

Forensic Biochemistry

E

3

BCH 416

BCH 413

Molecular Aspect of Immunology

E

2

BCH 417

 

Toxicology II

E

2

BCH 418

 

Biochemical Reasoning

C

1

BCH 419

BCH 408

Special Topics/Seminars in Biochemistry

C

2

BCH 430

BCH 406

Endocrinology

C

2

BCH 431

BCH 409

Biomembranes

C

2

TOTAL UNITS OF COMPULSORY COURSES:

UNITS OF ELECTIVE COURSES AVAILABLE:

             Total:

12

12

22

 

 

400 LEVEL SECOND SEMESTER

COURSE CODE

 

COURSE TITLE

STATUS

UNITS

BCH 420

BCH 420

Research Project

C

4

BCH 421

BCH 411

Biotechnology

E

3

BCH 422

BCH 416

Tissue Biochemistry

E

1

BCH 423

BCH 309/404

Molecular Biology

C

3

BCH 424

BCH 403

Metabolic Regulations

C

2

BCH 425

BCH 410

Plant Biochemistry

E

2

BCH 426

BCH 412

Food Biochemistry

E

2

BCH 427

BCH 415

Clinical Biochemistry

E

2

BCH 428

 

Bioinformatics

E

2

BCH 429

BCH 404

Genetic Engineering

E

2

BCH 440

 

Microbial Biochemistry

E

2

TOTAL UNITS OF COMPULSORY COURSES:

TOTAL UNITS OF ELECTIVE COURSES AVAILABLE:

                             Total:

09

15

25

GRADUATION REQUIREMENT

UTME Students

For a UTME student to graduate in B.Sc. (Hons) Biochemistry programme, the student must take and pass a minimum of 128 units including all compulsory courses.

 

Direct Entry Students

For a student to graduate in B.Sc. (Hons) Biochemistry programme, the student must take and pass a minimum of 96 units including all compulsory courses (80 units of compulsory courses which includes all GST courses).

This minimum will include:         

  • All University requirements: GST 102, 103, 105, 201, and 307. (10 units)
  • All Faculty Requirements: FSC 111, 112, 113, 114, 115, 311,  FRE137 & FRE147 (21 units)
  • Departmental Requirements: All Compulsory courses
  • Electives – ONLY from those listed in the curriculum and allowed by the department.

COURSE CONTENT

BCH 211: Introductory Biochemistry I (2 Units)

Introductory chemistry of amino acids; their properties, reactions and biological functions. Classification of amino acids: neutral, basic and acidic; polar and non-polar; essential and non-essential amino acids. Introductory chemistry of proteins; methods of their isolation, purification and identification. Primary, secondary, tertiary and quaternary structures of proteins.Basic principles of tests for proteins and amino acids.Biological functions of proteins.Introductory chemistry of carbohydrates, lipids and nucleic acids.Nomenclature of nucleosides, and nucleotides; effects of acid and alkali on hydrolysis of nucleic acids.

Pre-requisite: CHM 121

 

BCH 212: General Biochemistry Practical I (1 Unit)

Laboratory experiments designed to reflect the topics covered in BCH 211, BCH 213 and BCH 222. Introduction to laboratory methods and procedures employed in studying biochemical processes.            

Pre-requisite: CHM 121

 

BCH 213: Acid Base Chemistry (3 Units)

Acid- Base Chemistry-Ionisation of acids and bases, Definition of pH, pK, pKa, pI, Henderson-Hasselbach equation, Buffer systems, pH measurements and indicators. Chemical Kinetics- derivation of reaction rate constants, equilibrium reactions, derivation Keq, Activation energy and reaction rates. Thermodynamics-Definition of 1st and 2nd laws of thermodynamics, derivation of δG, δH, and δS. Atomic/Molecular Structure and Selected Organic Compounds-Identification of functional groups, nomenclature of organic compounds by IUPAC system. Atomic and molecular structures of simple organic compounds, orbit hybridization. Selected Properties of Organic molecules.

 

BCH 222: Introductory Biochemistry II (3 Units)

The cell theory. Structures and functions of major cell components. Cell types, constancy and diversity. Cell organelles of prokaryotes and eukaryotes. Chemical composition of cells. Centrifugation; Methods of cell fractionation. Structure, function and fractionation of extra-cellular organelles. Enzymes. Water and bio-molecules: protein, carbohydrates, lipids etc. Enzymes as Biological Catalyst.Classes of enzymes. Classification of proteins. Properties and functions of Proteins.Amino acid composition of proteins. Determination of primary structure of proteins; N-and C- terminal amino acids determination. Functions of nucleic acids, DNA as genetic material, Primary structure of Nucleic acids.Structure of RNA and DNA.Properties of DNA in solution.Sequencing of DNA.

Pre-requisite: BCH 211

 

BCH 212: General Biochemistry Practical I (1 Unit)

Laboratory experiments designed to reflect the topics covered in BCH 211 and BCH 222.

Introduction to laboratory methods and procedures employed in studying biochemical processes.

 

BCH 310: Bioenergetics (1 Unit)

High-energy compounds; Chemical potentials, Electrochemical potentials, Electron transport system and oxidative phosphorylation; Regulation of ATP production. Chemical thermodynamics; Oxidations and reductions.

BCH 311: Introductory Enzymology (3 Units)

Discovery, classification and nomenclature of enzymes. Vitamins and co-enzymes; minerals in enzyme biochemistry. Fat and water soluble vitamins. Structures and functions of vitamins and co-enzymes. Genetics of enzymes.Enzyme inhibition.Mechanisms of enzyme-catalysed reactions. Effects of temperature, pH, ions and inhibitors on enzyme catalysed reactions. Derivation and significance of Michaelis-Menten equation. Allosteric/Regulatory enzymes. Active sites of enzymes. Estimation of kinetic parameters of enzyme activities. Zymogen activation, digestive enzymes etc. Production, isolation, purification and characterization of enzymes. Recent advances in enzymology. Vitamins and Coenzymes.Industrial, clinical and other applications of enzymes.

 

BCH 312: Chemistry and Metabolism of Carbohydrates (2 Units)

Chemistry and function, isolation and purification of polysaccharides. Molecular weight determination and analytical methods for structural determination of polysaccharides. Biochemistry of important oligosaccharides and polysaccharides Degradation and digestion of carbohydrates – sugars, storage polysaccharides and cell walls. Glycolysis, the tricarboxylic acid cycle, the phosphogluconate pathway, the glycoxylate pathway; the pentose phosphate pathway and the Cori cycle: The Calvin pathway. Gluconeogenesis and glyconeogenesis. Regulation of carbohydrate metabolism. Disorders of carbohydrate metabolism.

Pre-requisite: BCH222

 

BCH 313: Chemistry and Metabolism of Lipids (2 Units)

Classification of lipids – fatty acids, triglycerides, glycosylglycerols, phospholipids, waxes, prostaglandins.Lipid micelles, monolayers, bilayers.Lipoprotein systems, transport protein of blood plasma.Oxidation of fatty acids.Microsomal peroxidation of polyunsaturated fatty acids.Metabolism of unsaturated fatty acids; essential and non-essential.Metabolism of acylglycerols.Degradation and turnover of phospholipids.Cholesterol biosynthesis and breakdown.Formation of ketone bodies.Integration of lipid metabolism.Acetic acid as a central precursor for biosynthesis of lipids.

Pre-requisite: BCH222

 

BCH 314: Analytical Methods in Biochemistry (3 Units)

Tissue and cell culture techniques, immunoassays, blotting, and isotopic techniques. Principles, methodologies, instrumentation and applications of electrophoresis, manometry and centrifugation techniques. Chromatographic techniques including paper, thin layer, column, gas, and high performance chromatographic techniques.Spectroscopic techniques including uv-visible, infra-red, nuclear magnetic resonance and mass spectrometry.Fluorimetry, polarographic including potentiometric and electrometric measurements. This course includes laboratory practical classes which will provide students opportunity to practice the various techniques and familiarise themselves with the types of equipment used for the techniques.

Pre-requisite: BCH 222

 

BCH 315: General Biochemistry Practical II (2 Units)

Laboratory methods and procedures employed in studying biochemical processes cutting across a wide spectrum of general biochemistry. Cell fractionation/extraction, Analysis and Partial characterization of macromolecules.Basic Chromatographic techniques.Spectrophotometric analysis of biomolecules.Principles, procedures and application of centrifugation techniques in characterization and quantification of macromolecules.Principles, procedures and application of spectrophotometric techniques in characterization and quantification of macromolecules.Isolation, purification and characterization of enzymes and measurement of enzyme activity-methods and principles.

BCH 316: General Biochemistry (Non-Majors)       (3 Units)

General outlines of basic chemistry of biological polymers, carbohydrates, proteins, lipids, nucleotides and polynucleotides. Elementary enzyme kinetics. Metabolism of lipids, amino acids and proteins.Metabolism of Carbohydrates, Glycolysis, TCA, etc.Vitamins and cofactors.Special topics to include photosynthesis, hormones (plant and animal) detoxification mechanisms.

BCH 320: Principles of Endocrinology (2 Units)

Organization of the mammalian endocrine system.Chemistry and functions of hormones, mechanism of hormone action.Storage and secretion of hormones.Steroid hormones, thyroid hormones, parathyroid hormones.Role of intercellular receptors, hormone responsive elements, enhancer elements, fusion genes, Peptide hormones.Role of cyclic AMP as a second messenger.Adenylatecyclase system, protein kinase C, phosphoproteins, phosphodiesterase, phosphatases, guanylatecyclase, G. proteins.Hormones acting through calcium and phosphoinositides, calmodulin-calcium system as a mediator of hormones.Structure and synthesis of insulin.Prostaglandins.

BCH 321: Principles of Immunology (2 Units)

Blood chemistry and composition.  Preparation of serum and plasma. Protein components of plasma.Innate and acquired immunity.Antigens, antibodies, cellular immunity.Antigen-antibody interactions.Immunological tolerance and suppression.Immunological anomalies, diagnostic immunology, vaccines.Structure of immunoglobulins. Combining sites of antibodies. Myeloma and hybridomaimmunoglobulins. The antigen binding site. Domains of antibody molecules-gene duplication and diversification.Generation of diverse antibody specificities, clonal selection theory of antibody formation.Biological significance of clonal selection.

 

BCH 322: Chemistry and Metabolism of Amino Acids & Proteins (2 Units)

Amino acids as building blocks of proteins; the peptide bond as covalent backbone of proteins. Forces involved in the stabilization of protein structure. Protein isolation, fractionation, purification and characterization.Amino acid analysis of peptides and proteins.Methods for the determination of the sequence of amino acids in proteins.Molecular weight determination of proteins.Techniques in protein biochemistry.Oxidative degradation of amino acids and metabolism of one carbon units.Ammonia toxicity and urea formation.Biosynthesis of amino acids and some derivatives; the urea cycle; metabolism of inorganic nitrogen.Disorders of amino acid metabolism.

Pre-requisite: BCH222

 

BCH 323: Chemistry and Metabolism of Nucleic Acids (2 Units)

Structure and function of nucleic acids.DNA replication and protein synthesis.DNA repairs. The genetic code and protein synthesis. Metabolism of purines and pyrimidines, nucleosides and nucleotides.Degradation of purine and pyrimidine nucleotides.Abnormalities in nucleic acid metabolism-xeroderma pigmentation and skin cancer.

Pre-requisite: BCH222

 

BCH 324: Nutritional Biochemistry (2 Units)

An introduction to the theory and application of physical and chemical methods for determining the constituents of food. Food processing, preservation and storage of traditional foods – root and stem tubers, fruits and fruit drinks, seeds and grains, greens and vegetables. Food poisoning and intoxication; prevention and cure. Food nutrients; Energy values of foods and energy expenditure by mammalians.Nutritive value of foods – carbohydrates, fats, proteins, vitamins, mineral elements and water. Nutritional disorders, prevention and therapy. Nutritional status and nutritional requirements. Recommended dietary allowances. Assessment of nutritional status.Nutrient requirements in relation to physical activity and ageing, diet and disease, obesity and under nutrition.

 

BCH 325: Toxicology I (2 Units)

Basic principles of toxicology, definition and scope; absorption and distribution of toxicants; toxicokinetics, metabolism of toxicants; comparative toxicology; elimination of toxicants and their metabolites, toxicant-receptor interactions, genetic poisons, chemical carcinogenesis; trace element toxicity, hepatotoxicity.

 

BCH 410: Advanced Biochemical Methods (Practical) (2 Units)

The purpose of this course is to familiarise students with operations of latest biochemical equipment and with methods of research, assimilation and dissemination of information. Students will therefore go round lecturers and laboratories housing specialized equipment with the aim of exposing them to such equipment under the supervision of lecturers. Part of the course will also cover the effective use of the library, preparation of dissertations or theses, papers for journal publications and journal reviews. Special assignments and essays will be given to students.

Pre-requisite: BCH314

 

BCH 411: Enzymology (2 Units)

Chemistry of enzyme catalysis. Steady state enzyme kinetics. Transport kinetic methods. Ligand binding and its application to enzymology. Kinetics of multiple binding sites. Mechanisms of two substrate systems. Molecular models of allosterism. Enzyme models of allosterism. Multi-enzyme complexes. Enzyme assays and techniques in enzymology. Criteria for determining purity of enzymes. Enzyme reconstitution. Regulation of enzyme activity and synthesis.

Pre-requisite: BCH311

BCH 412: Biosynthesis of Macromolecules (1 Unit)

Structures and functions of macromolecules. Biosynthesis and storage of polysaccharides, mucopolysaccharides, glycoproteins. Bacterial cell wall synthesis of complex lipids, lipoproteins and nucleic acids.

 

BCH 413: Pharmacological Biochemistry (2 Units)

Cellular metabolism in infected cells. Biochemical aspects of host-parasite relationships. Metabolic factors affecting chemotherapeutic agents. Theories of the mechanism of drug action. Drug resistances and other factors affecting drug efficacy. The physiological and biochemical.

 

BCH 414: Bioinorganic Chemistry (1 Unit)

Relationship between the physicochemical properties and biological functions of inorganic ions. Ligand complexes and their biochemical significance. Electrolyte metabolism. Nitrogen fixation and sulphur cycle.

 

BCH 415: Forensic Biochemistry (3 Units)

Procedure for the extraction of contaminants of forensic interest from tissues. Collection and preservation techniques for materials of forensic interest. Analytical procedures in forensic science. Law, science and medicine in forensic practices.

 

BCH 416: Molecular Aspects of Immunology (2 Units)

Immune type and manifestation. Basis of immune response. Autoimmunity; cancer and immune response. Immunoanalytical techniques.The immunosuppressive drugs/agents.

Pre-requisite: BCH321

BCH 417: Toxicology II (2 Units)

Biological effects of toxic substances in living organisms. Metabolism, cellular and tissue targets, mechanisms of action, and pathological effects. Resistance and tolerance of toxicants, natural toxicants, chronic testing in animals; tests for mutagenicity in toxicological evaluation of chemicals; isolation and structural elucidation of toxicants; enzymatic detoxification.

Pre-requisite: BCH325

 

BCH 418: Biochemical Reasoning (1 Unit)

Evaluation and design of experimental biochemistry from available information and data. Analysis, interpretation and inference – drawing from biochemical research data.

 

BCH 419: Special Topics/Seminar in Biochemistry (2 Units)

Hormones, immunochemistry, oncology, brain biochemistry, monoclonal antibodies. These may be taught or seminars may be given by students.

 

BCH 430: Endocrinology (2 Units)

Hormones: Biochemistry and molecular mechanism of action, cyclic AMP. Hormone receptors: isolation and properties. Diabetes mellitus and hypoglycemia. Biochemistry and functions of insulin and other hormones controlling carbohydrate metabolism. The thyroid hormones: biochemistry and functions. The steroid hormones; mineralocorticoids and glucocorticoids.

Pre-requisite: BCH320

 

BCH 431: Membrane Biochemistry (1 Unit)

Structure, composition and functions of biological membranes. Isolation, characterization and classification of membranes; chemistry and biosynthesis of membranes.Molecular organization of membrane components.Natural and artificial membrane bilayers-the unit membrane hypothesis. Membrane transport system – active versus passive transport systems. Transport of sugars and amino acids.

Pre-requisite: BCH313

 

 

BCH 420: Research Projects (4 Units)

Independent research findings into selected areas/topics of interest to the supervising academic staff. Students will be required to carry out literature survey on the topics, perform experiments and produce reports (preferably at the end of second semester). Students will be subjected to both seminar and oral examination on the projects undertaken.

Pre-requisite: BCH315

 

BCH 421: Biotechnology (3 Units)

A short review of microbial physiology and genetics.A review of general metabolic pathways and application in industrial processes.Continuous culture methods, principles and applications.The chemostat and its application in industrial fermentations.Primary and secondary metabolism.Process evaluation and development.Over production of metabolites – amino acids, taste enhancers, vitamins, toxin etc.Methods for screening and selecting micro-organisms of industrial importance.Induction of mutation in micro-organism and plants for the purpose of over production; Strain selection/development and enhancement.Gene dosage and its application in industrial processes.

 

BCH 422: Tissue Biochemistry (1 Unit)

Biochemistry of muscles, kidney, liver, and adipose tissues. General metabolism of the brain and neuronal biochemistry. Biochemistry of reproductive tissues. Detoxification and excretion in tissues.

 

BCH 423: Molecular Biology (3 Units:) Pre-requisite: BCH323

Gene structure and function. Nucleic acid function and biological function.DNA sequencing and restriction endonucleases. DNA repair mechanisms. Nucleic acid replication. Regulation of nucleic acid synthesis. Genetic code and gene-protein relationship. Eukaryotic transcription. Control of gene expression.Functional analysis of the replicator structure of bacteriophage DNA.Drug-nucleic acid interactions.Initiation factor for viral DNA replication.Genetic control of viral replication. Model systems used for studying embryology at the molecular level. Model systems in differentiation studies. Control of cell proliferation. Genetic engineering and recombinant gene technology.

 

BCH 424: Metabolic Regulations (2 Units)

The relationship of Krebs’ Cycle to protein, carbohydrate, lipid and nucleic acid metabolism. Integration of metabolic pathways. Turn-over rates and metabolic pools.

Regulation of enzymes of metabolic pathways-feed back inhibition versus enzyme synthesis. Catabolite repression, end product repression. Identification of different regulatory mechanisms in metabolic pathways.

 

BCH 425: Plant Biochemistry (2 Units)

Organization of plant cells. The biochemistry of important plant processes and metabolic pathways. Photosynthesis; alkaloids, flavonoids and plant hormones. Biosynthesis of carotenoid pigments. Biochemistry of plant development. The plant cell wall structure, formation and growth. Lignin formation. Free amino acids, pyrimidines, purines and nucleosides in plants. Metabolism of auxins, gibberellins and cytokinins.Synthetic growth regulators and herbicides. Structure – activity relationship of plant hormones.

 

BCH 426: Food Biochemistry (2 Units)

Biochemical changes in food – meat, fish, and fruits. Enzymatic browning and bio-deterioration of food products – vegetable and oils, milk and milk products, cereal formulas and food additives. Functional foods.

 

BCH 427: Clinical Biochemistry (2 Units)

The theoretical biochemical basis of laboratory tests of clinical significance in diagnosis and management of diseases. Intracellular organization, structure and functions of specialized tissues – liver, kidney muscles, adipose tissue, elastin, collagen, brain, Functional aspects of neural biochemistry membrane potential and ion transport.Neurotransmitters and biogenic amines in the brain.Constitution and function of blood, lymph and other fluids.Biochemistry of vision.

 

BCH 428: Bioinformatics (2 Units)

Definition, goal, scope, applications and limitations of bioinformatics.Introduction to biological databases – classification of biological databases, common databases such as NCBI GenBank, PDB, EMBL, SwissProt etc. Introduction to bioinformatics tools – BLAST, Clustal W, NEB Cutter, etc. Descriptions of various bioinformatics software and the differences between tools and software with practical examples such as spdb viewer, Modeller, Autodock etc. Structural bioinformatics: Protein structure, visualization, comparison, classification and prediction; RNA structure prediction. Introduction to genomics and proteomics.

 

BCH 429: Genetic Engineering (2 Units)

Recombinant – DNA technology. Gene cloning and applications.Plasmids.Restriction enzymes.Cloning and expression vectors. Methods for transforming host cell. Southern and Northern blotting and applications.Polymerase Chain Reaction and applications.Polynucleotide sequence determination.Site-Directed Mutagenesis.Mutation screening techniques.Gene therapy.

Pre-requisite: BCH323

 

BCH 440: Microbial Biochemistry (2 Units)

Metabolism of biomolecules in parasites contrasted with that of the host. Host/parasite interaction, parasite nutrient needs. Biochemical mechanisms of drug action against parasitism.Defense mechanism.Biomembranes of parasites.Mechanism of infection by virus.Survey of structural properties of different classes of viruses.Viral multiplication mechanisms.Control of viral replication.Interferon.